In Silico Study of Physalis angulata Active Compound from Bromo Tengger Semeru Nasional Park as Anti-Inflammation
Yuslinda Annisa, Siti Nur Arifah, Fatchur Rohman, Dwiyono Hari Utomo, Purwanto, Sri Rahayu Lestari
Universitas Negeri Malang
Abstract
The tribes in Indonesia are vary. Tengger tribe is one of the Indonesian tribes that located in Bromo Tengger Semeru NationalPark (BTSNP). BTSNP area has a very high diversity of plants. Various types of plants were used by Tengger Tribe in any field such as medicine, food sources including animal feed, industry and households, building materials, ecology, and traditional rituals. Based on interview with key informant called ‘Dukun- and Tengger tribe local people were found that Physalis angulata (local name: Ciplukan gunung) is the most used within Tengger tribe. They used P. angulata to treat any kind of diseases especially keep heart and lung in healthy condition. Tengger tribe used P. angulate by boiling in certain time then drink it as a tonic. The aims of this research were to analyze active compound from decoction of P. angulate that has anti-inflammatory agent. High Performance Liquid Chromatography (HPLC) result showed that decoction of P. angulate contained with active compound, one of them was Benzaldehyde. In silico study between benzaldehyde and cyclooxygenase 1 (COX-1) resulted that benzaldehyde has potency as inhibitor for COX-1. COX-1 is involved in inflammatory pathway. The inhibition towards COX-1 resulted on decreasing of inflammation. P. angulate has function as anti-inflammation.
Keywords: Tengger tribe, Bromo Tengger Semeru National Park (BTSNP), Physalis angulata, anti-inflammation, Cyclooxygenase 1 (COX-1)
Topic: Bioinformatics