Anticancer Potential of Holothurin A, Holothurin B, dan Holothurin B3 from the sea cucumber Holothuria sp.
Teresa Liliana Wargasetia (a*), Hana Ratnawati (a), Widodo (b)

a) Faculty of Medicine, Universitas Kristen Maranatha,
Jl. Prof. drg. Suria Sumantri MPH 65 Bandung 40164, Indonesia
* Teresa.lw[at]med.maranatha.edu
b) Biology Department, Faculty of Mathematics and Natural Sciences, The University of Brawijaya, Jl. Veteran Malang 65145, Indonesia

Abstract

Sea cucumbers have a wide distribution and high abundance in Indonesia. Previous research has shown that sea cucumbers have an anticancer function and have toxicity to various types of cancer cells. Furthermore, we identified the anticancer compounds of the sea cucumber Holothuria sp. collected from South Malang sea. Holothuria sp was extracted using methanol, then the active compound content was analyzed using liquid chromatography–mass spectrometry (LC-MS). From the results of the analysis, it is known that the methanol extract of Holothuria sp. contains 3 types of anticancer compounds namely holothurin A, holothurin B, and holothurin B3. Based on in silico analysis, it is estimated that the holothurin compounds have target proteins namely BCL2 and PTPN2 which play an important role in the process of apoptosis and cell cycle. The results of this study show that sea cucumbers can be used as anticancer, although various in vitro and in vivo tests are needed to prove the anticancer mechanism.

Keywords: anticancer, apoptosis, Holothuria sp., holothurin, sea cucumber

Topic: Biomedical Science

Link: https://ifory.id/abstract-plain/ECXqUycGxbKr

Web Format | Corresponding Author (Teresa Liliana Wargasetia)