Characterization and Antibacterial Activity of Dayak Onion (Eleutherine palmifolia) Hydrogel in Vitro
Uswatun Chasanah1, A. B. Apriliyanto1, Dika Anggara1, Ayu Kusumawardani1 and Dian Ermawati1
1Department of Pharmacy, Health Science Faculty, University of Muhamamdiyah Malang 65145, East Java, Indonesia
uswatun,dianerma[at]umm.ac.ud, bagasapril4,anggara.dika96, ayu7662[at]gmail.com
Abstract
Traditionally, the crushed bulbs of Dayak onion (Eleutherine palmifolia) used for wound healing due to naphthoquinone compounds found in the bulbs of Dayak onion can inhibit the growth of Staphylococcus aureus, Staphylococcus epidermis, and Pseudomonas aeruginosa that cause skin infection. To improve the ease of using the bulbs of Dayak onion as drugs for the treatment of wounds that need to be made in the appropriate dosage form is a topical hydrogel, hydrogels contained Dayak onion extract at a level of 2%, 4.5%, and 6.0% were made then determined its characterization which included organoleptic, pH, viscosity, and spreadability, determined of antibacterial activity by a well-diffusion method. The higher levels Dayak onion extract resulted in hydrogels which homogenous, sharp color intensity, more aromatic, decreased viscosity, and increased spreadability while for pH was not different, while the highest antibacterial activity achieved by Dayak onion hydrogels 6.0% which had antibacterial effectiveness to the Staphylococcus aureus, Staphylococcus epidermis, and Pseudomonas aeruginosa were 59.2%, 49.5%, and 63.1%, respectively, and as control was tetracycline HCL 1.0%. Thus, the Dayak onion hydrogels 6.0% is the best.
Keywords: Eleutherine palmifolia, Hydrogel, Antibacterial, Staphylococcus aureus, Staphylococcus epidermis, Pseudomonas aeruginosa
Topic: Pharmaceutical Science