Correlation of CD8+ T Cell and IFNγ Level as an Immune Response in HIV/AIDS Patients with Co-Infection with Pulmonary Tuberculosis at UPIPI Dr. Soetomo Hospital Surabaya
Jessika Virgiana(1), Hartono Kahar(2), Pudji Lestari(3), and Lisa Savitri(4)
(1)Department of Immunology, Postgraduate School, Universitas Airlangga, Surabaya, East Java, Indonesia
(2)Department of Clinical Pathology, RSUD Dr. Soetomo, Surabaya, East Java, Indonesia
(3)Department of Public Health and Preventive Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia
(4)Department of Health Analyst, Faculty of Health Science, Universitas Kadiri, Kediri, East Java, Indonesia
Abstract
One of the diseases whose prevalence continues to increase and needs serious attention in the GBD is Acquired Immune Deficiency Syndrome (AIDS). The number of new cases of HIV in 2014-2016 was 104,896, the number of cases was quite large in the province of East Java with 15,176 people. Patients with AIDS show damaged CD8+ T cells (CTL), even though HIV does not infect CD8+ T cells. This is because CD4+ T cells (the main target of HIV) are needed for the response of CD8+ T cells to antigens. HIV infection reduces the number of CD4+ T cells and cytokines released by T lymphocytes, such as interferon-γ (IFN-γ) and interleukin-2 (IL-2). After an HIV positive patient is exposed to Mycobacterium tuberculosis, IFN-γ decreases, reducing the response of helper 1 T cells (TH1). This study is an observational study with a cross sectional study design that is analytical. Representative data was performed on whole blood and analyzed on a dual-laser BDFACS brand flow cytometer with laser excitation at 488 nm and 635 nm. The results of this study are that there is no significant relationship between CD8+ count and IFN-γ in HIV-infected patients with pulmonary tuberculosis infection at UPIPI Dr. Soetomo Hospital Surabaya. The greater the count of CD8+ respondents, the higher the IFN-γ level will tend to be.
Keywords: CD8+ T cell, IFN-γ level, HIV/AIDS patient
Topic: Health and Medicine