Microemulgel Formulation of Kepok Banana Skin Extract (Musa paradisiaca L) as an antioxidant
FF Sriarumtias1, A Akmal2, A Najihudin1, IR Putri1, , S Hamdani1

1Program Studi Farmasi, Fakultas MIPA Universitas Garut, Jl. Raya Samarang No. 52A Garut, Indonesia

2Lembaga Farmasi Direktorat Kesehatan Angkatan Darat, Jl. Gudang Utara No. 26 Merdeka, Sumur Bandung, Kota Bandung, Jawa Barat

Abstract

Banana skin only becomes organic waste without being able to take advantage, so the purpose of this study is to utilize kepok banana skin into microemulgel which are stable and have antioxidant activity. The skin of kepok banana was extracted using maceration method with methanol solvent. The resulting extracts were then tested for antioxidant activity with the DPPH (1,1-diphenyl-2-pikrilhidrazil) method, obtained IC50 values of 659,544 ppm. Concentration extract in microemulgel formulation is one IC50 (F1), twice IC50 (F2), three times IC50 (F3) and positive controls containing vitamin C (F4). All formulas were evaluated including organoleptic, pH, viscosity, centrifugation, dispersion, irritation test and freeze and thaw. The evaluation results show that only formula F3 changes organoleptically and decreases viscosity. The testing of antioxidant activity microemulgel containing banana skin extract showed that F2 was the best formula on pharmaceutical requirements with the the IC50 638 ppm and good stability. For all formulas after an irritation test, no erythema or udema were found, so the irritation index was zero. The benefits of this study can provide an alternative source of phytocosmetic preparations as antioxidants and utilizing organic waste into something useful.

Keywords: antioxidant, banana skin extract, dpph, microemulgel

Topic: Pharmacology

Link: https://ifory.id/abstract-plain/LjDAzGhgdUcF

Web Format | Corresponding Author (Framesti Frisma Sriarumtias)