THE DIFFERENCES OF KIDNEY FUNCTION TEST IN HEMODIALYSIS PATIENTS SERUM WITH AND WITHOUT DILUTION
Subrata Tri Widada1, EniKurniati2
Health Polytecnic Yogyakarta
Abstract
Kidney is a important organ in the human body, the body will have problems if the kidney does not work properly. Treatments for the disease may include hemodialysis. Patient of hemodialysis is often found high creatinine, ureum, and uric acid levels. This condition may affect the quality of laboratory results. According to The Beer-Lambert-s Law, the portion of the light absorption will depend on how many molecules it interacts with. However, the theory cannot be applied to a solution with high concentration. This condition can trigger inaccurate results which may be harmful to the patients because it cause errors in diagnosis, treatment and disease monitoring. This condition can be handled by diluting the concentrated serum. A serum sample was diluted with a physiological saline solution (NaCl). This study aims to determine the level of kidney function test in hemodialysis patients serum with and without dilution. This research was Pre-experimental Design methods with One-Group Pretest-Posttest Design. Research sample was used serum of hemodialysis patient with creatinine level more than 10 mg/dL, ureum level more than 256 mg/dL, and uric acid level more than 12mg/dL counted 40 samples. The test results were analyzed descriptively and statistically using Paired Sample T-Test. The mean of creatinine and uric acid levels increase was 2.29 mg / dL (16.72%) and 4.02 mg / dL (44.47%), while the mean urea decreased was 19.52 mg / dL (6.38 %).The results tested with Paired Sample T-Test showed a significant 0.000 (<0.05) which means there was a difference of kidney function test in hemodialysis patients with and without dilution.
Keywords: Kidney Function Test, Hemodialysis, Without Dilution, Dilution.
Topic: MEDICAL LABORATORY TECHNOLOGY