Preparation and Physical Characterization of Meloxicam Transdermal Patches Reservoir Type
Ginanjar Putri Nastiti(a*), Esti Hendradi(b), Devi Ristian Octavia(a)
a). Pharmaceutics Department, Faculty of Health Sciences, Pharmacy Study Program, Universitas Muhammadiyah Lamongan, Raya Plalangan street KM.3, Plosowahyu, 62218, Lamongan, East Java, Indonesia;
b). Pharmaceutics Department, Faculty Pharmacy, Airlangga University, Dharmawangsa street No.4-6, Airlangga, Gubeng, 60286, Surabaya, East Java, Indonesia
Abstract
Meloxicam transdermal patches reservoir type were aimed to be prepared in order to overcome the problems by oral routes especially happened in Gastrointestinal (GI) tract. The strategy was formulation of optimized polymers to prepare transdermal patches reservoir type by determination of physical properties and investigation of compatibility of drug and excipient. Meloxicam transdermal patches reservoir type were prepared by 2 polymers, hydroxypropyl methyl cellulose (HPCMC) as rate controlling membrane and carboxymethyl chitosan (CmC) as drug reservoir. The meloxicam transdermal patches were evaluated for their physical properties such as visual physical characteristic (visual), surface test with scanning electron microscopy (SEM), moisture content, weight uniformity, thickness, and drug content. Those data were analyzed using MANOVA with degree of confident 95% (&
Keywords: Patch, Meloxicam, HPMC, Carboxymethyl Chitosan
Topic: International Symposium of Engineering, Technology, and Health Sciences