Differences in the effectiveness of Metformin and Gliclazide to Lower Blood Glucose in Type 2 Diabetes Mellitus Outpatient in The Sanjiwani Hospital
Sagung Putri Permana Lestari Murdhana Putere, Pande Putu Bagus Mahendra Yasa

Faculty of Medicine and Health Sciences, University of Warmadewa

Abstract

Nowadays, type 2 diabetes mellitus (T2DM) is the most prevalence of diabetes mellitus disease. In Indonesia 10 millions people suffering T2DM which caused Indonesia ranked seventh in the world and predicted to increase 16.2 millions patients on 2040. The use of oral antidiabetic drugs (OAD) like metformin and gliclazide still an option on T2DM therapy. This study aims to determine the differences in the effectiveness of metformin and gliclazide to lower blood glucose in patient T2DM in the sanjiwani gianyar hospital. The variable of this study is oral antidiabetic drugs and blood glucose. The design of this study using cross sectional analitic observational approach with retrospective study. The sample of this study is patient T2DM in internal medicine policlinic of Sanjiwani Gianyar Hospital from Januari-Desember 2016 with 160 subjects who selected through consecutive sampling and fulfil the inclusion and exclusion criteria. This study using secondary data in form of medical record. The data was analyzed by chi square test (α=0.05). The results was showed that the effectiveness of each OAD to decrease blood glucose for 3 months therapy, the used of metformin showed that (70%) 56 sample achieved controlled blood glucose while the used of gliclazide showed that (52.5%) 42 sample achieved controlled blood glucose and there was a significant differences in the effectiveness of metformin and gliclazide with p value is 0.035. The conclusions of this study is metformin more effective than gliclazide to lower blood glucose in T2DM outpatient and advices who gived to hospital, health workers and community.

Keywords: Type 2 diabetes mellitus, Effectiveness, Metformin, Gliclazide, Blood glucose

Topic: Biology

Link: https://ifory.id/abstract-plain/QNqvYrDhcdmK

Web Format | Corresponding Author (Dewa Ayu Putri Sri Masyeni)