The Role of Echocardiography in Assessing Improvement of Cardiac Function After Administration of β-1,3/1,6-D-Glucan (Polysaccharide Peptide) of Miselia Ganoderma lucidum Extracts in Post-Myocardial Infarction Patients : A Double-Blind Randomized Controlled Trial
Liemena Harold Adrian (a,b*), Peter Sugita (c), Djanggan Sargowo (a,b)
a) Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University – Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia
b) Research Center of Degenerative Disease, Malang, East Java, Indonesia
c) PT Sahabat Lingkungan Hidup, Surabaya, East Java, Indonesia
*Correspondence email : liemenaharold[at]gmail.com
Abstract
Background : Bioactive polysaccharide component of Miselia Ganoderma lucidum (β-1,3/1,6-D-Glucan) has proven beneficial to prevent coronary artery disease (CAD) in high-risk patients. Its role on the improvement of cardiac function assessed by echocardiography in post myocardial infarction (MI) patients is still unknown. Methods : This was a single-center, randomized double-blind clinical trial in post MI patients who had undergone reperfusion or conservative therapy or surviving acute phase. 45 of total 50 patients were selected and divided into treated and control groups. The treated group was given 540 mg β-1,3/1,6-D-Glucan polysaccharide peptide (PsP) of Ganoderma lucidum extracts in 3 divided dose for 90 days, and the latter was receiving placebo. A Morisky score was used to evaluate patients- adherence to treatment. Echocardiographic examination was measured as a standard manner by two standardized physician. All statistical analysis were 2-sided using SPSS version 24.0. Results : At 90 days, β-1,3/1,6-D-Glucan PsP of Ganoderma lucidum extracts significantly improved left ventricular ejection fraction (LVEF) (P=0.008), left ventricular mass index (LVMI) (P=0.043), left ventricular internal diameter in diastole (LVIDd) (P=0.000), relative wall thickness (RWT) (P=0.017), regional wall motion abnormality (RWMA) (P=0.021) and left ventricular diastolic dysfunction (P=0.000) compared to placebo. However, no significant improvement was found in left ventricular fractional shortening (FS) and tricuspid annular plane systolic excursion (TAPSE) (P=0.24 and P=0.20; respectively). Conclusion : The role of β-1,3/1,6-D-Glucan polysaccharide peptide (PsP) of Ganoderma lucidum extracts significantly improve cardiac function in post myocardial infarction patients.
Keywords: Ganoderma lucidum, polysaccharides peptide, β-1,3/1,6-D-Glucan, echocardiography, myocardial infarction
Topic: Health and Medicine