SUPPLEMENTATION OF 2:1 OF N-6:N-3 PUFA RATIO REDUCES BODY FATNESS IN YOUNG OBESE BALINESE WOMEN: A RANDOMISED STUDY WITH OPTIMISED ENERGY REGULATION
I Wayan Weta*, Wayan P. Sutirtayasa*, Safarina G. Malik**
* Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia
** Eijkman Institute for Molecular Biology, Ministry of Research Technology and Higher Education, Republic of Indonesia, Jakarta, Indonesia
Abstract
Background and Objectives: Obese Indonesians, including Balinese, are at higher risk of co-morbidities like, CVD, diabetes, non-alcoholic fatty liver disease. Urban Balinese are changing their diet from traditional to fast foods and the like that are high in saturated fats. Nutritional modification, such as increasing n-3 PUFA content in the diet, may aid in managing body fat accumulation-related diseases. This study investigated the effects of supplementation of n-6:n-3 PUFA with ratio of 2:1 on body fat reduction in young obese Balinese women. Methods and Study Design: Sixty-six young obese Balinese women, aged 18-25, were randomly assigned equally into Intervention and Control groups, supplemented with 2100 mg:1100 mg and 240 mg:100 mg of n-6:n-3 PUFAs, respectively. Data were collected at baseline, 6, and 12 weeks of intervention. BMI, waist circumference (WC), waist-to-height ratio (WHtR), conicity index (CI), triglyceride concentrations, and Lipid Accumulation Product (LAP) were measured. The participants were advised to maintain <1500-Kcal daily energy intake and participate in a guided low-impact aerobics once a week. Results: After 12-weeks supplementation, all body fat indices (BMI, WC, WHtR, CI, and LAP), decreased significantly weather were unadjusted or adjusted by the reduced of energy intake in the Intervention group. Otherwise, in the Control group only some of WC indices (WC, WHtR, and CI) decreased stasticically. BMI and WC of the Intervention group decreased significantly more than the Control group. Conclusion: Twelve-week intervention with high-dose of low n-6:n-3 PUFAs ratio and restriction energy intake, reduced body fatness selectively in young obese Balinese women
Keywords: low n-6:n-3 PUFA ratio, young obese Balines women, body fat
Topic: Nutrition and Quality of life