Bcp-Collagen Gel Biomaterial Bone Graft Formulation as Alternative Bone Implant
Yudith Violetta Pamulang(1*), Setyo Budhi(2), Vigha Ilmanafi Arifka(3), Josi Emmanuel Aldo Pramono(4), Mellya Permatasari(1), Khairul Anam(1)

1 Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281
2 Department Surgery and Radiology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281
3 Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281
4 Faculty of Engineering, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281

Abstract

Fracture is disconnection of bone continuity caused by trauma, pressure, or pathological disorder. On the other hand, fracture healing is a complex process and needed a long time to rejoin without leaving wound. To fasten this process, an implant material is needed as a replacement for damaged bone tissues. Biphasic calcium phospate (BCP) is a biomaterial phase of the building materials of bone and teeth, and collagen in bone implant is a structural protein that helps osteoblast mediators. This research is aimed to create formula from biphasic calcium phospate (BCP) and collagen in gel preparation as drug delivery system and bone filler. Gel bonegraft is made in two formulas with different compositions: 1) Formulation 1 (10% collagen in gel), 2) Formulation 2 (15% collagen in gel). Evaluation of gel preparation comprises of organoleptic, and pH testing. Test results show that the preparation is white in color, has smooth texture, semisolid form, pH of 5 - 6. Both gel formulation can be used to deliver bonegraft biomaterial on each bone fragments.

Keywords: Fracture; bonegraft; biomaterial; gel; Biphasic Calsium Phosphate

Topic: Health Technology and Medical Treatment

Link: https://ifory.id/abstract-plain/VBWTDE7Y9FyG

Web Format | Corresponding Author (Yudith Violetta Pamulang)