In-silico Based Analysis of ANGPTL-8 in Fibrinogenesis Through Tumor Growth Factor β-receptor 1 Signaling Pathway
Hendra Susanto1*, I Kade Karisma Gita Ardana1, Melati Putri Pertiwi1, Elhah Nailul Khasna1, Abdul Ghofur1, Adeodatus Yuda Handaya2,3, Nia Lukita Ariani4
1) Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia
2) Faculty of Medicine, Universitas Gadjah Mada, Indonesia
3) Department of Digestive Surgery, Dr. Sardjito Hospital, Yogyakarta, Indonesia
4) Department of Nursing Sciences, Tribhuwana Tunggadewi University, Indonesia
*Corresponding Author-s email: hendrabio[at]um.ac.id
Abstract
Liver fibrogenesis can turn out into liver cirrhosis and being a fatal failure. Infection of HBV and metabolic syndrome is the major causes of liver fibrogenesis. ANGPTL8 is the hormones that interact with many factors related to HBV infection and metabolic syndrome. The purpose of this study was to crosscheck computational based interaction of ANGPTL8 and TGFβ1 on TGFβR1 as the pathological signal that related to liver fibrogenesis. Our study shows that ANGPTL8 bind better onto TGFβ1R than TGFβ1 so that ANGPTL8 may implicate with fibrogenesis through simultaneous binding into TGFβ1R with TGFβ1. This study work as an initial study that can be used as the basis of the next study to determine the role of ANGPTL8 in the occurrence of liver fibrogenesis due to metabolic syndrome and HBV infection.
Keywords: ANGPTL-8, liver fibrinogenesis, TGFβ1R, hepatocellular carcinoma
Topic: Bioinformatics