STEROID COMPOUNDS FROM THE STEMBARK OF Aglaia simplicifolia (Meliaceae) AND CYTOTOXIC EFFECTS AGAINST HELA CERVICAL CANCER CELL LINES
Nunung Kurniasih(a*), Asep Supriadin(a), Hersa Milawati(b), Rizky Abdulah(c), Desi Harneti(b), Unang Supratman(b,d), Mohamad Nurul Azmi B Mohamad Taib(e)
(a)Department of Chemistry, Faculty of Sciences and Technology, Sunan Gunung Djati Islamic State University, Bandung 40614, Indonesia
(b)Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
(c)Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia
(d)Central Laboratory of Universitas Padjadjaran, Jatinangor 45363, Indonesia
(e)School of Chemical Sciences, Universiti Sains Malaysia,11800 Minden, Penang, Malaysia
* Corresponding author: nunungkurniasih[at]uinsgd.ac.id
Abstract
Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified on the basis of spectroscopic evidence including UV, IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. The cytotoxic effects against HeLa cervical cancer cell lines of the extracts and compounds were studied.
Keywords: Aglaia simplicifolia, steroid, HeLa cervical cancer cell lines.
Topic: Chemistry