Fabrication of Silica/Fe2.18Zn0.82O4 Nanocomposite as Drug Carrier System
Ahmad Taufiq 1*, Anindya Bella Monica 1, Ainun Nikmah 1, Arif Hidayat 1, Sunaryono 1, Nurul Hidayat 1, Hendra Susanto 2, Laemthong Chuenchom 3
1 Department of Physics, Universitas Negeri Malang, Indonesia
2 Department of Biology, Universitas Negeri Malang, Indonesia
3 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Prince of Songkla University, Thailand
Abstract
In this work, we report the synthesis and characterization of silica/Fe2.18Zn0.82O4 nanocomposite and its performance as drug carrier system for doxorubicin. The silica/Fe2.18Zn0.82O4 nanocomposite was synthesis via co-precipitation and hydrolysis routes. Based on the data analysis of crystallographic characterization, the silica/Fe2.18Zn0.82O4 nanocomposite formed in nanometric size of approximately 7.14 nm. The elemental characterization presented that Zn, Fe, and Si were detected in constructing silica/Fe2.18Zn0.82O4 nanocomposite. Moreover, the functional groups of Fe-O, Zn-O, and Si-O-Si were identified at the various wavelength originating from silica/Fe2.18Zn0.82O4 nanocomposite. Interestingly, the silica/Fe2.18Zn0.82O4 nanocomposite exhibited excellent performance as drug carrier for doxorubicin detected from absorbance and stability behaviours.
Keywords: Silica, Fe2.18Zn0.82O4, nanocomposite, doxorubicin, carrier.
Topic: Biomaterial Science