The Potential of Vanillin Derivative Compounds as Antibacterial Agents
Rini Retnosari1*, Sutrisno2, Meyga Evi Ferama Sari3, Ihsan Budi Rachman4, Yaya Rukayadi5
1,2,3,4Department of Chemistry, Faculty of Mathematics and Natural Sciences, State University of Malang
5Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Abstract
Vanillin is one of the compounds that was successfully isolated from the fruits of the Vanilla planifolia Andrews which are abundant in Indonesia. So far, Indonesia has only been able to export vanilla fruit directly without further processing. The IUPAC name of Vanillin is 4-hydroxy-3-methoxybenzaldehyde. This compound is a derivative of benzaldehyde. The presence of an aldehyde group causes vanillin to experience a Knoevenagel condensation reaction if it is reacted with dimedone. In this paper, two derivatives of vanillin compounds successfully synthesized. The first compound has a pyran skeleton and the second compound has a pyridine skeleton. Both of these compounds have the potential as antibacterial agents against gram positive and negative bacteria.
Keywords: vanillin derivatives, Knoevenagel condensation, antibacterial agents
Topic: Biomedical Science