Preparation and Characterization of Fe3O4/PEG Nanoparticles Combined with Curcumin for Drug Delivery Application
Ahmad Taufiq 1, Kusnunnahari 1, Nurul Hidayat 1, Arif Hidayat 1, Hendra Susanto 2, Sunaryono 1, Laemthong Chuenchom 3
1 Department of Physics, Universitas Negeri Malang, Indonesia
2 Department of Biology, Universitas Negeri Malang, Indonesia
3 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Prince of Songkla University, Thailand
Abstract
In the last decades, doxorubicin has been widely used for cancer treatment combined with magnetic nanoparticles. Therefore, the development of utilization of magnetic nanoparticles as drug carrier for cancer treatment becomes essential to be done. In this work, we report the preparation of Fe3O4/PEG nanoparticles combined with curcumin as drug delivery agent for doxorubicin. The samples were characterized by means of XRD, FTIR, XRF, and UV-Vis spectrometer. The data analysis of the characterization showed that the spinel crystal structure was detected for both Fe3¬O4/PEG and Fe3-O4/PEG/curcumin. However, the presence of curcumin leaded to decrease its crystallinity and didn-t change significantly the particle size. The functional groups of Fe3¬O4/PEG sample were evaluated at the wavenumber 587.285 cm-1 for Fe-O. The wavenumber of 1108 cm-1 and 2883 cm-1 were originated from C-O-C and C-H. Meanwhile, for the Fe3¬O4/PEG/curcumin sample, despite the functional groups of Fe-O, C-O-C, and C-H, the functional group of -OCH3¬ at the wavelength of 1153.4 cm-1 was detected originated from curcumin. Moreover, based on the drug loading and drug release characterizations for doxorubicin, the Fe3¬O4/PEG and Fe3¬O4/PEG/curcumin exhibited good performance as drug delivery carrier.
Keywords: Fe3O4, PEG, curcumin, nanoparticle, drug carrier.
Topic: Biomaterial Science