ANTIHYPERLIPIDEMIA ACTIVITY OF Eleutherine palmifolia Merr. ETHANOL EXTRACTS ON WISTAR STRAIN RATS
Doni Anshar Nuari (a*), Cindra Tri Yuniar (b), Aditya Siswanto (a), Sitti Fatimah Putri Hasyul (a), Tita Puspita (a)
a)Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Garut, Garut, Indonesia
* doni[at]uniga.ac.id
b) School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, Indonesia
Abstract
Hyperlipidemia is a heterogeneous disorder that is usually characterized by increased levels of total cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), triglycerides, and decreased levels of high-density lipoprotein (HDL) associated with an increased risk of coronary heart disease. Eleutherine palmifolia Merr. was used to treat hyperlipidemia so that this study was conducted to determine the antihyperlipidemic activity of ethanol extract of Eleutherine palmifolia Merr. Tests were carried out by exogenous and endogenous induction of Wistar strain white rats using high-fat foods and propylthiouracil. The parameters seen were total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol. The results of research are at a dose of 100 mg/kgBW gave the best effect by reducing total cholesterol, LDL-cholesterol and triglyceride levels significantly different from positive controls (p <0.05). So that from the ethanol extract of Eleutherine palmifolia Merr. Has an antihyperlipidemic effect.
Keywords: Antihyperlipidemia, Cholesterol, Eleutherine palmifolia Merr, Triglycerides
Topic: Pharmacology