DISSOLUTION PROFILE OF PARACETAMOL TABLETS WITH CHICKEN FEET GELATIN AS BINDER COMPARED WITH COMMERCIAL COW GELATIN
Aji Najihudin (a*), Nurhabibah (a), Ayustina Permata (a), Nurul Auliasari (a), Framesti Frisma Sriarumtias (a)
a) Fakultas MIPA, Universitas Garut (UNIGA), Garut, Indonesia
*ajinajihudin[at]uniga.ac.id
Abstract
Gelatin is a biopolymer derived from collagen proteins extracted from the skin or animal bones.The aim of this research was to formulated paracetamol tablets by using chicken feet gelatin, evaluated tablets and dissolution test. The preparation of chicken feet gelatin was done by an acid method using 4% HCl solvent. Preparation of paracetamol tablets using chicken feet gelatin and commercial gelatin was done by wet granulation method with the variation of binder concentration of 1.5%, 3%, and 4.5%. The granules, tablets, and dissolution tests were evaluated. Testing of in vitro dissolution of paracetamol tablets was done by paddling method in phosphate buffer pH 5.8 as dissolution medium. The yield of chicken feet gelatin obtained was 5.06%. The results of evaluation paracetamol granules and tablets showed that six formulas are qualify except for the friability of F1 and F2. Paracetamol tablets using chicken feet gelatin as binder showed a faster dissolution profile and qualify compared to commercial gelatin binders. Paracetamol tablets using chicken feet gelatin as the binder with a concentration of 4.5% (formula 3) showed the best results of tablets evaluation and in the 30th minute dissolve as much as 81.55%, it showed the best dissolution profile.
Keywords: Disolution, Paracetamol, chicken feet gelatin, wet granulation
Topic: Pharmacology