Cytotoxic Activity of Flavonoid Compound from Endophytic Fungus Fusarium sp. Associated from Phyllantus Niruri Linn. Leaves
Rollando Rollandoa*, Yuyun Yuniatib, Eva Monicaa, Leny Yuliatib
aProgram of Chemistry, Faculty of Science and Technology, Universitas Ma Chung,
Malang, Indonesia
bProgram of Pharmacy, Faculty of Science and Technology, Universitas Ma Chung,
Malang, Indonesia
Abstract
Endophytic fungus was alternative source of cytotoxic metabolites derived from plant. CHCl3 fraction of ethyl acetate extract endophyte fungal genus Fusarium sp. of meniran leaves (Phyllanthus niruri Linn.) proved have cytotoxic activity in T47D breast cancer cells. This study aims to explore the active cytotoxic activity. IR, LC-MS, 1H-NMR, 13C-NMR, DEPT, and HMQC spectra showed ,3-dihydro-7-hydroxy-2-(3-hydroxyphenyl)chromen-4-one compounds. Isolate has IC50 value to T47D cells of 13.87 μg/mL and to Vero cells of 163.98 μg/mL.
Keywords: Endophytic fungus, Fusarium sp, T47D, Vero, 2,3-dihydro-7-hydroxy-2-(3-hydroxyphenyl)chromen-4-one.
Topic: Pharmaceutical Science