The Correlation Between Urinary Albumin-Creatinine Ratio and The Stage of Renal Failure in Type 2 Diabetes Mellitus Patients in Bali
Asri Lestarini (a*), AA Sri Agung Aryastuti (a), Ni Putu Diah Witari(a), I Wayan Sutarka (b), I Made Agus Sastrawan (b), Ni Wayan Sri Wardani (c), I Wayan Eka Saputra (c), Pramudji Hastuti (d), Ahmad Hamim Sadewa (d)
(a) Faculty of Medicine and Health Sciences, Warmadewa University
Jalan Terompong no 24 Denpasar, 80235, Indonesia
*asrilestarini[at]gmail.com
(b) Tabanan Hospital, Bali, Indonesia
(c) Sanjiwani Hospital, Bali, Indonesia
(d) Faculty of Medicine, Gadjah Mada University, Indonesia
Abstract
Diabetic nephropathy is one of the complications caused by metabolic disease which could lead to renal failure. A marker that can potentially be used for early detection of diabetic nephropathy is urinary albumin-creatinine ratio (uACR). This study aimed to measure correlation between uACR and the stage of renal failure. Crosssectional study was conducted in March until August 2018. Participants were clinically examined, and blood and urine were taken. the stages of renal failure was determined by estimated Glomerular Filtration Rate (eGFR). Data was statistically analyzed by One way ANOVA and Pearson correlation. Of 107 participants, 79 participants were eligible for inclusion in data analysis. The participants were grouped into 5 stages of renal failure. Urinary albumin-creatinine ratios in stage 1,2,3,4,5 were 204.9, 125.9, 474.9, 604.7 and 2895.6 respectively. Posthoc analysis showed significant differences in uACR between stage 5 and stage 1,2,3 respectively (p<0.05). Significant correlations were found in uACR with SC (r 0.354, p 0.001), BUN (r 0.244, p 0.032) and eGFR (r -0.345, p 0.02) respectively. Urinary albumin-creatinine ratio had positive correlation with serum creatinine and blood urea nitrogen, while had a negative correlation with estimated glomerullar filtration rate
Keywords: renal failure, urinary albumin-creatinine ratio
Topic: Biology