The Potencyof Green Grass Jelly Extract(Premna oblongifolia Merr) as AntihyperlipidemiaTowards Malondialdehyde Level MDA) Rat (Rattus norvegicus) Induced with High Fatty Diet (HFD)
Eka Nora Vitaloka Aprilia P.W , Anna Roosdiana, Dyah Ayu Oktaviani A.Pratama

Program Studi Magister Imunologi, Sekolah Pascasarjana, Universitas Airlangga
Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Brawijaya
Program Studi Dokter Hewan, Fakultas Kedokteran Hewan, Universitas Brawijaya

Abstract

Hyperlipidemia is the increase of blood lipid level consists of lipoprotein (cholesterol and triglyceride). Green grass jelly (Premna oblongifolia merr) is a plant containing fiber and chlorophyll which can lower cholesterol and triglyceride levels. The aim of this study was to investigate the potency of green grass jelly extract (Premna oblongifolia Merr) to prevent hyperlipidemia which is indicated by malondialdehyde level (MDA) of rat induced with High-Fatty Diet (HFD). This study was carried out using male rat (Rattus norvegicus), Wistar strain, the age of 8 weeks, and weight of 200 g which is divided into 5 groups of treatment namely group Kn (negative control), Kp (positive control), P1, P2, and P3 induced with HFD and green grass jelly extract at a dose of 5.27 g/ kg BW/ daily, 8.43 g/ kg BW/ daily, 9.37 g/ kg BW/ daily. The green grass jelly extract was dissolved in water and delivered by sonde, followed by HFD induction similarly with green grass extract, HFD composed of 1 g quail egg yolk; 2 g butter; 2 g cow fat. The MDA level was measured with Thiobarbituric Acid (TBA) reagent spectrophotometrically. The data of MDA level was analyzed using ANOVA and continue with Tukey. This research showed that treatment of green grass jelly extract (Premna oblongifolia Merr) to animal of hyperlipidemia model reduced malondialdehyde level (MDA). The conclusion of this study was the green grass jelly extract was able to prevent the increase of malondialdehyde (MDA) level of rat (Rattus noervegicus) induced with HFD on dose 9,37 g/ kg/ BW/ daily.

Keywords: hyperlipidemia, High Fatty Diet (HFD), green grass jelly, malondialdehyde (MDA)

Topic: Health and Medicine

Link: https://ifory.id/abstract-plain/qJUxBAGD69Hg

Web Format | Corresponding Author (Eka Nora Vitaloka Aprilia Putri Winthoko)