Effect Of Propoxur To The Level Of Estradiol And Estradiol Reseptor In Rat
Arni Amir1*, Eryati Darwin2, Hasmiwati3
Department of Biology, Faculty of Medicine, Universitas Andalas
Abstract
Propoxur is classified as bad actor because of its high toxicity. If inhaled or absorbed the body can obscure vision, excessive sweating, dizziness, headache, and weak body. Propoxur also decreases the activity of enzymes that play a role in nerve transmission, and adversely affects the liver and reproduction. Propoxur is a middle class poison. If inhaled or absorbed by the human body can obscure vision, excessive sweating, dizziness, headache, and weak body. Propoxur can also reduce enzyme activity which plays a role in nerve transmission, and adversely affects the liver and reproduction. Study aimed to determine the effect of propoxur exposure toward estradiol level and estradiol receptors in Rattus novergicus female. The experimental rats were divided into 4 groups, namely: the first group of control groups as many as 8 groups were not given treatment, the second group was the treatment group (P1) this group was given propoxur 1 spray for 30 minutes, the third group (P2) this group was given propoxur 2 spray for 60 minutes, and the third group (P3) is given propoxur 3 times the spray for 90 minutes, the estrus cycle is examined every time estrus. Collection of serum and ELISA examination on hormone levels of estradiol and its receptors Results showed there were significant differences between the control group and the treatment group exposed to Propoxur for 30 minutes (19.5869 ± 4.9731), 60 minutes (20.0920 ± 5.7529), and 90 minutes (25.8703 ± 4.0753). There was a long-standing effect of Propoxur toward Estradiol hormone (p = 0.000). There were also significant differences of estradiol receptor (p = 0.008) between the control group and the treatment group exposed to Propoxur for 30 minutes (1.8489 ± 0.9017), 60 minutes (2.3844 ± 1.4296), and 90 minutes (3.1634 ± 0.9936). Based on statistical tests, it concluded that there is a long-standing effect of Propoxur. The longer exposure to Propoxur the higher the level of estradiol receptors.
Keywords: propoxur, estradiol hormone and estradiol reseptor
Topic: Health Technology and Medical Treatment