Toxicity of Papaya (Carica papaya) Seed Extract on Wistar White Rat
Sri Wahyuni, Fendy Hardian Permana*, Adjar Yusrandi Akbar
Department of Biology Education.
Faculty of Teacher Training and Education.
Universitas Muhammadiyah Malang
Abstract
One of the biological agents that have many benefits is papaya seed (Carica papaya). On the other hand, papaya seeds also contain some chemical compounds that have toxic properties such as papain and karpain. The aim of this study was to examine the acute toxicity of papaya seed extract by looking at the mortality rates in the population and reviewing the physiological effects manifested by its behavior. Behavior that measured such as the general behavior, aggressiveness and tail movement. The method used to test acute toxicity is by LD50 Miller and Stainter method then categorized its toxicity threshold. Then the emerging physiological impact was analyzed by Likert scale and given the score. After that the data is tested with normality test and one way anova. Toxicity test showed that LD50 extract of papaya seed extract was 18.62 g / kg BW and categorized as practically non toxic. Then there is the effect of papaya seed extract on behavioral physiological and aggressiveness. There was no effect of various doses of papaya seed extract on mouse tail movements
Keywords: Toxicity of papaya seed; Wistar white rat
Topic: Biomedical Science