Immunomodulatory Activity of Steroid Saponins in Dioscorea alata L. Tubers In Silico
Sri Nabawiyati Nurul Makiyah (a*), Sri Tasminatun (b), Tri Wulandari Kesetyaningsih (c), Sabtanti Hari Murti (b)

a) Histology and Cell Biology Department, School of Medicine, Faculty of Medicine and Health Sciences,
Universitas Muhammadiyah Yogyakarta, Daerah Istimewa Yogyakarta, Indonesia
b) School of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta, Daerah Istimewa Yogyakarta, Indonesia
c) Parasitology Department, School of Medicine, Faculty of Medicine and Health Sciences,
Universitas Muhammadiyah Yogyakarta, Daerah Istimewa Yogyakarta, Indonesia

corresponding author: nurul_makiyah[at]umy.ac.id

Abstract

Steroid saponin in the tuber of Dioscorea alata L. has the potential to have immunomodu-latory activity. The purpose of this study was to examine the immunomodulatory activity of steroid saponins in Dioscorea alata L. tubers in silico. This observational study was conducted using steroid saponin compounds as a result of GC-MS test N-hexan extract, Clionasterol with comparison of native ligand (Celecoxib) which was carried out molecular docking using COX-2 receptors with Chimera software. The docking process uses a protein with the code: 3LN1, which is the active side of the COX-2 receptor which binds to celecoxib (a drug that selectively binds to the COX-2 receptor). Validation results between COX-2 receptor proteins binding to native Ligand (Celecoxib) show Lower Bond RMSD values &

Keywords: Steroid Saponins, Dioscorea alata L., in silico, immunomodulators, Clionasterol

Topic: International Symposium of Engineering, Technology, and Health Sciences

Link: https://ifory.id/abstract-plain/w6f8Wn3XDqvF

Web Format | Corresponding Author (Sri Nabawiyati Nurul Makiyah)