The Chronic Effect of Green Tea (Camellia sinensis L.) Drinking on Triglyceride and Total Cholesterol Serum Level in Alloxan-Induced Diabetic Male Rats (Rattus norvegicus)
Rauza Sukma Rita (1*), Biomechy Oktomalioputri (2), Eka Kurniawan (3)
1) Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Jalan Perintis Kemerdekaan No.94 PO BOX 49, Jati, Padang, Indonesia
*Corresponding author: rauzasukmarita[at]med.unand.ac.id
2) Department of Histology, Faculty of Medicine, Universitas, Padang, Indonesia
3) Department of Internal Medicine, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, Indonesia
Abstract
Background : Diabetes melitus is metabolic diseases which characterized by hyperglycemia that occurs due to abnormality of insulin secretion, insulin action, or both. In diabetes melitus, either type 1 or type 2 diabetes, abnormalities of lipoprotein metabolism could be found. Green tea contains of a lot of antioxidant and may influenced lipoprotein metabolism. Purpose of this research was to determine the effect of green tea on LDL levels in diabetes mellitus rats. Purpose : Purpose of this research was to determine the effect of green tea drinking on triglyceride and total cholesterol serum levels in diabetes melitus rats. Methods : This research was an experimental research conducted on 27 male rats. Rats were divided into 5 groups (negative control, positive control, and tretament group). Positive and treatment group were injected by alloxan (150 mg/kg BW), and treatment group were given green tea drinking with 3 doses (27 mg/200 g BW/day, 54 mg/200 g BW/day, and 81 mg/200 g BW/day) for four weeks. In the last day of research, blood were collected and triglyceride and total cholesterol serum level were examined Results : Green tea drinking decreased both triglyceride and total cholesterol serum level significantly compared to positive control group. Conclusion : Green tea drinking has a lowering effect on triglyceride and total cholesterol serum level in diabetes melitus
Keywords: green tea, chronic effect, alloxan, triglyceride, total cholesterol, diabetes melitus
Topic: Communicable and Non Communicable Diseases