The evaluation of dietary single bulb garlic (Allium sativum) extract in lipid profile in high fat diet mice (Mus musculus)
Alif Rofiqotun Nurul Alimah, Siti Nur Arifah, Yuslinda Annisa, Betty Lukiati, Nuning Wulandari, Sri Rahayu Lestari

Universitas Negeri Malang

Abstract

Single bulb garlic contains high sulfur compounds and widely used to reduce cholesterol. The imbalanced between Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL), increase of Triglyceride (TG) and total cholesterol will trigger various diseases including atherosclerosis. This study aimed to analyze the lipid profiles in mice fed a high-fat diet and treated with single bulb garlic extract. This research used twenty-four eight-week-old mice Balb/C grouped into six groups; normal diet (ND), high-fat diet (HFD), HFD with 26 mg/kg BW simvastatin (HFD + simv), HFD with single bulb garlic extract (SBGE) 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW respectively. Simvastatin and SBGE administrated daily for thirty day. At the end of the research, mice were sacrificed, then blood was collected from the heart and sentrifuged to obtain serum. Data were analyzed with one-way ANOVA. The results showed that administration of a SBGE was able to restore HDL and LDL concentration and reduce cholesterol and tryglyceride levels significantly (p<0.05) in mice with HFD. Our result suggest that SBGE could use as supplement or therapy to treat atherosclerosis.

Keywords: Single bulb garlic, high fat diet, lipid profile, atherosclerosis

Topic: Biomedical Science

Link: https://ifory.id/abstract-plain/9nGrAFQL7ujN

Web Format | Corresponding Author (Alif Rofiqotun Nurul Alimah)