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Single bulb garlic contains high sulfur compounds and widely used to reduce cholesterol. The imbalanced between Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL), increase of Triglyceride (TG) and total cholesterol will trigger various diseases including atherosclerosis. This study aimed to analyze the lipid profiles in mice fed a high-fat diet and treated with single bulb garlic extract. This research used twenty-four eight-week-old mice Balb/C grouped into six groups; normal diet (ND), high-fat diet (HFD), HFD with 26 mg/kg BW simvastatin (HFD + simv), HFD with single bulb garlic extract (SBGE) 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW respectively. Simvastatin and SBGE administrated daily for thirty day. At the end of the research, mice were sacrificed, then blood was collected from the heart and sentrifuged to obtain serum. Data were analyzed with one-way ANOVA. The results showed that administration of a SBGE was able to restore HDL and LDL concentration and reduce cholesterol and tryglyceride levels significantly (p<0.05) in mice with HFD. Our result suggest that SBGE could use as supplement or therapy to treat atherosclerosis.