THE EFFECT OF TEMPERATURE IN THE APPLICATION OF MESOPOROUS NANOMATERIALS BASED ON CARBON IN DRUG DELIVERY SYSTEM WITH IBUPROFEN
Maria Ulfa (a*), Reni Alfi Ardini (a), and Didik Prasetyoko (b)
a) Study Program of Chemistry Education, Faculty of Teacher Training and Education, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java Indonesia
*ulfa.maria2015[at]gmail.com
b) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Jl. Keputih, Surabaya, East Java Indonesia
Abstract
In this study, we synthesized mesoporous carbon using SBA-15 as template and sucrose as carbon precursor. Mesoporous carbon produced by using hard template method in this study are labeled MNbC were then characterized using Instrument Fourier Transform Infrared Spectrophotometer (FTIR), Small-angle X-Ray Diffraction (SAXRD), Scanning Electron Microscopy (SEM). In this study, mesoporous carbon is used to adsorb Ibuprofen using hexan solvent and the temperature variation experiment at 0°C, 37°C, and 45°C as the innovation of the drug delivery system. The drug delivery system is evaluated in a simulated body fluid after ibuprofen loading process. The results of the experiments showed that the optimum adsorption capacity of the trial temperature is 45°C it was due to a relationship between temperature and surface tension.
Keywords: drug delivery system, mesoporous carbon, ibuprofen, temperature
Topic: Sciences