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In this study, we synthesized mesoporous carbon using SBA-15 as template and sucrose as carbon precursor. Mesoporous carbon produced by using hard template method in this study are labeled MNbC were then characterized using Instrument Fourier Transform Infrared Spectrophotometer (FTIR), Small-angle X-Ray Diffraction (SAXRD), Scanning Electron Microscopy (SEM). In this study, mesoporous carbon is used to adsorb Ibuprofen using hexan solvent and the temperature variation experiment at 0°C, 37°C, and 45°C as the innovation of the drug delivery system. The drug delivery system is evaluated in a simulated body fluid after ibuprofen loading process. The results of the experiments showed that the optimum adsorption capacity of the trial temperature is 45°C it was due to a relationship between temperature and surface tension.