AKTIVITAS HEPATOPROTEKTOR NANOPARTIKEL CURCUMA LONGA L. TERHADAP FUNGSI SINTESIS ALBUMIN DAN CHOLINESTERASE PADA TIKUS PUTIH DIINDUKSI CCl4
Juniarti (a), Insan Sosiawan A Tunru (b), Indra Kusuma(c*), Endah Purnamasari (b), Fathir Rizki Suwandi (d), Indah Permata Yuda (e)
(a) Pusat Studi Herbal, Departemen Biokimia Fakultas Kedokteran, Program Studi Sains Biomedis Sekolah Pascasarjana Universitas YARSI, Jakarta
(b)Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas YARSI, Jakarta
(c) Departemen Fisiologi Fakultas Kedokteran, Program Studi Sains Biomedis Sekolah Pascasarjana Universitas YARSI, Jakarta
(d) Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas YARSI, Jakarta
(e) Pusat Studi Herbal Universitas YARSI, Jakarta
Abstract
CCl4-induced damage of the liver among others are the disruption of albumin and cholinesterase synthesis. Curcuma longa. L is a herb that has been known indigenously as a hepatoprotector and prevent damage to the liver. However, due to the low bioavailabiliy in the blood hampers its used in clinical settings. Nano-encapsulation of the curcuma extract may increase its bioavailability. Objective. This study aim to provide the evidence of nano-encapsulated curcuma hepatoprotective activity in CCL4-induced rat. Methodes. This study used 24 male Sprague-Dawley rat in eight groups comporised of (1) control group, (2) Control CCl4-induced group, (3) CCl4-induced rat with commercially available curcumin preparation, (4) CCl4-induced rat with 250 and (5) 500 mg/body weight curcuma extract, (6) CCl4-induced rat with 125, (7) 250 and (8) 500 mg/body weight nano-encapsulated curcuma extract. Albumin and cholinesterase were quantified from peripheral blood. Results. This study shows a significant increase of albumin and cholinesterase blood concentration in group using curcuma extract and nano-encapsulated curcuma extract compared to other group. Conclusion. Nano-encapsulated curcuma extract can protect the liver from CCl4-induced damages
Keywords: nanoparticle, Curcuma longa. L, Hepatoprotector, CCl4.
Topic: Farmasi Klinis dan Komunitas