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CCl4-induced damage of the liver among others are the disruption of albumin and cholinesterase synthesis. Curcuma longa. L is a herb that has been known indigenously as a hepatoprotector and prevent damage to the liver. However, due to the low bioavailabiliy in the blood hampers its used in clinical settings. Nano-encapsulation of the curcuma extract may increase its bioavailability. Objective. This study aim to provide the evidence of nano-encapsulated curcuma hepatoprotective activity in CCL4-induced rat. Methodes. This study used 24 male Sprague-Dawley rat in eight groups comporised of (1) control group, (2) Control CCl4-induced group, (3) CCl4-induced rat with commercially available curcumin preparation, (4) CCl4-induced rat with 250 and (5) 500 mg/body weight curcuma extract, (6) CCl4-induced rat with 125, (7) 250 and (8) 500 mg/body weight nano-encapsulated curcuma extract. Albumin and cholinesterase were quantified from peripheral blood. Results. This study shows a significant increase of albumin and cholinesterase blood concentration in group using curcuma extract and nano-encapsulated curcuma extract compared to other group. Conclusion. Nano-encapsulated curcuma extract can protect the liver from CCl4-induced damages