WOUND HEALING ACTIVITY OF Hemigraphis colorata ETHANOL LEAVES EXTRACT ON BURNS
Lusi Putri Dwita, Vera Ladeska, Aisyah Ramadhani, Dwi Rahma Augusta, Retno Tri Saufia
Universitas Muhammadiyah Prof. DR. HAMKA
Abstract
Remek daging (Hemigraphis colorata W.Bull) have been studied and used traditionally for wound healing. This study aimed to determine the effect of topical application of 70% ethanol extract of Remek daging leaves on burn wound. The animals used for this study were 30 rats, divided into 5 groups namely 20, 10, 5% Remek daging extract ointment, negative control (Vaseline flavum) and positive control (Burnazin®). Observations were held on days 3, 7 and 14 histologically. Histological observations show an increase in the number of macrophages, fibroblasts, collagen density and re-epithelialization in the extract ointment group significantly compare to the negative control (p <0.05), and at a concentration of 20% showed comparable results to Burnazin® (p> 0.05). It can be concluded that Remek daging ointment extract can accelerate the healing of burn wound with the best results at a concentration of 20%.
Keywords: Hemigraphis colorata; burns; macrophages; fibroblasts; collagen
Topic: Farmakologi dan Klinik TOOT