Effect of Gabus Extract (Channa striata) on Increase the Number of Wistar Rat Fibroblast Induced Periodontitis
Rasmidar Samad, Hasanuddin Thahir, and Dian Setiawati
Public Dental Health Department, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia.
Periodontology Department, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia.
Abstract
Abstract Objective: This study aimed to define the effect of Gabus extract on the healing of Wistar rat induced periodontitis through histopathological examination. Methods: The study design used post-test with control group design, with two sample groups. Each sample group would be sacrificed and histopathological examination was performed to calculate the number of fibroblasts. Twenty-four Wistar mice with health conditions in the early stages were induced by periodontitis using a combination of silk ligature and Porphyromonas gingivalis bacteria. The slide observed using a microscope with 400x magnification to count of fibroblasts cell of each group. Results: Two-way ANOVA test and t-test produced significant differences [p<0.05] between the treatment groups of Gabus extract and the control group. Conclusion: Gabus extract could increase the number of Wistar rat fibroblasts induced by periodontitis.
Keywords: Channa Striata; Fibroblast; Gabus Extract; Periodontitis
Topic: Nutrition and Quality of life