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Abstract Objective: This study aimed to define the effect of Gabus extract on the healing of Wistar rat induced periodontitis through histopathological examination. Methods: The study design used post-test with control group design, with two sample groups. Each sample group would be sacrificed and histopathological examination was performed to calculate the number of fibroblasts. Twenty-four Wistar mice with health conditions in the early stages were induced by periodontitis using a combination of silk ligature and Porphyromonas gingivalis bacteria. The slide observed using a microscope with 400x magnification to count of fibroblasts cell of each group. Results: Two-way ANOVA test and t-test produced significant differences [p<0.05] between the treatment groups of Gabus extract and the control group. Conclusion: Gabus extract could increase the number of Wistar rat fibroblasts induced by periodontitis.