The impact ofred dragon fruit (Hylocereus polyrhizus)extract on reducing cholesterol level in pregnant animal model
Reskiawati Azisa, Gemini Alamb, Samrichardc
aDepartment of Midwifery, Graduate School, Hasanuddin University, Indonesia
bFaculty of Pharmacy, Hasanuddin University, Indonesia
cDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Indonesia
Abstract
Objective:This research aimed to prove that the giving of dragon fruit extract (Hylocereus polyrhizus) can influence the reducing of pregnant white rat-s cholesterol level (Rattus norvegicus) Method:It was a laboratory study used 25 white rats. Animal group was divided into 5 groups, i.e., a negative control group (standard feed), a positive control group (simvastatin 0.18 mg), and three treatment groups (a dosage of dragon fruit 18 mg/200 gram of body weight (BW), 27 mg/200gram of body weight and 45 mg/200gram of body weight). All groups were inducted into the enormously-fat feed. The treatment was given for seven days. The examination wasused cholesterol checkup tool, i.e., Easy touch EGC. Result: The result of the research shows that dragon fruit extract could reduce the cholesterol level. The average cholesterol level reduction in a negative control group is 58.60 mg/dl, a positive control group is 82.20 mg/dl, a treatment group of dragon fruit with a dose of 18 mg/200 gram of body weight is 119.40mg/dl, dragon fruit with a dose of 27 mg/200 gram of body weight is 132.40 mg/dl, and a dragon fruit with a dose of 45 mg/200 gram of body weight is 161.20 mg/dl. All cholesterol levels were statistically significant Conclusion: Dragon fruit extract hasan impact on reducing cholesterol level to pregnant white rat (Rattus novergicus).
Keywords: Cholesterol;Hypercholesterolemia; Dragon fruit extract
Topic: Herbal medicine