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Objective:This research aimed to prove that the giving of dragon fruit extract (Hylocereus polyrhizus) can influence the reducing of pregnant white rat-s cholesterol level (Rattus norvegicus) Method:It was a laboratory study used 25 white rats. Animal group was divided into 5 groups, i.e., a negative control group (standard feed), a positive control group (simvastatin 0.18 mg), and three treatment groups (a dosage of dragon fruit 18 mg/200 gram of body weight (BW), 27 mg/200gram of body weight and 45 mg/200gram of body weight). All groups were inducted into the enormously-fat feed. The treatment was given for seven days. The examination wasused cholesterol checkup tool, i.e., Easy touch EGC. Result: The result of the research shows that dragon fruit extract could reduce the cholesterol level. The average cholesterol level reduction in a negative control group is 58.60 mg/dl, a positive control group is 82.20 mg/dl, a treatment group of dragon fruit with a dose of 18 mg/200 gram of body weight is 119.40mg/dl, dragon fruit with a dose of 27 mg/200 gram of body weight is 132.40 mg/dl, and a dragon fruit with a dose of 45 mg/200 gram of body weight is 161.20 mg/dl. All cholesterol levels were statistically significant Conclusion: Dragon fruit extract hasan impact on reducing cholesterol level to pregnant white rat (Rattus novergicus).