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Incidence of dengue remains high in tropical and subtropical countries which makes dengue the most common arthropod-borne disease in the region. There is limited data on dengue virus serotype in Bali. This study aimed to assess clinical and virological characteristics of dengue patients in Bali. A cross sectional prospective study was conducted from September 2015 to August 2016. Clinical manifestations were obtained and viral RNA from patient sera were serotyped using conventional RT-PCR. One way Anova was used to compare the clinical manifestation within serotype. Of the 603 patients, 177 cases were confirmed as dengue positive and could be classified into four serotypes. DENV-1, DENV-2, DENV-3, DENV-4. The common clinical manifestations documented were malaise, nausea, anorexia, cephalgia, myalgia, vomiting, athralgia, abdominal pain, retroorbita pain and bleeding. The most prevalent symtoms of cephalgia, bleeding and adominal pain were with DENV-3 infection 63 (66.3%), 11 (11.6%) and 12 (12.6%) respectively. Clinical characteristics such as blood pressure, pulse, temperature, trombocyte, leucocyte, hematocrite and hemoglobin were recorded. Temperature was significantly high in DENV-3 (p 0.030)compared to other serotypes. From all the dengue serotypes that were detected, the most prevalent was DENV-3. There is no significant differences in the clinical manifestations among all serotypes except for high temperature in DENV-3 infection.