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The limitation in connecting the three levels of chemical representation is a major factor in the difficulty of learning the concept of chemical equilibrium. Computer-based molecular visualization and integrated three-dimensional animation can help students have representational capabilities by providing opportunities to present several levels simultaneously in various formats such as video, animation, and simulation. This study aims to create an e-module visualization of POE-based chemical equilibrium processes (Predict-Observe-Explain) which includes sub-concepts of dynamic equilibrium, homogeneous and heterogeneous equilibrium, and factors that influence chemical equilibrium. The three main activities in this e-module are predicting, observing and explaining. The e-module was created using the Design Based Research method with ADD design (Analysis, Design, Development) which was validated by two material expert lecturers and two multimedia expert lecturers producing an overall average calculation of 0.87 while the results of the feasibility test conducted at ten students show a percentage of 98.11%. This shows that this e-module is very suitable to be used as teaching material.