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Background: HIV increases susceptibility to various types of infections, cancer, other diseases and can cause death. Sleman is the highest case of HIV in Province DIY. Sleman Health Office records HIV/AIDS cases increased in 2015(1.038 cases) to 2016 (1.220 cases). WHO defines quality of life as an individual-s perception of their position in the cultural context and value system Research Objectives : to find out the correlation between the duration of diagnosed HIV with the quality of life (QOL) of people living with HIV/AIDS (PLWHA) at Yayasan Victory Plus in 2019. Research Methods: This study used a retrospective cohort design. Consecutive sampling used tofound 38 samples of respondents with HIV/AIDS at Yayasan Victory Plus. The research instrument was a questionnaire. Data analyzed by chi square and logistic regression. Results: The results of the Chi-Square test showed that duration of diagnosed HIV (p = 0.017) has significantly correlation with the quality of life PLWHA. Age, education, occupation, duration of ARV therapy, and income did not have a significant correlation. The results of multivariate analysis showed that the duration of diagnosed was the most influential factor of quality of life PLWHA (p-value = 0.002, RR = 96.404). Conclusion: Diagnosed duration of HIV has a significant correlation with the quality of life PLWHA. Respondents who were diagnosed for longer had the chance to have a poor quality of life. 8.3% PLWHA who are diagnosed longer and ≥ 30 years old have a poor quality of life.