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Exercise habits is one of the WHO recommendations as a form of non-pharmacological therapy in patients with diabetes mellitus (DM). DM is one of the public health problems in DIY, including in Bantul. Until now not much has been studied so that the purpose of this study was to find out how the description and relationship of exercise habits with hematogram and blood chemistry in DM patients at Jetis Health Center, Bantul. This study was conducted with a cross-sectional design in 99 patients at risk for DM. The inclusion criteria were male or female patients over 18 years old diagnosed with DM or had undergone antiDM drug therapy for 3 months and stated they were willing to study the subject. Interviews were conducted to obtain exercise habits data and hematogram and blood chemistry measurements (GDS, cholesterol and triglycerides) were carried out. Data is presented descriptively and analytically. The mean GDS, cholesterol and triglyceride levels were subjected to a mean difference test with one-way t test with 95% significance. The results showed that the majority of the research subjects were women, basic education, private employment, no smoking, exercise habits, average blood cavern level and fasting were higher than the target, as well as the mean level triglyceride levels. Hb levels, leukocyte count, platelet counts and erythrocytes within normal limits. The cholesterol level of the test subject is also within the normal range. The results showed that the Hb and hematocrit levels of the exercise group were higher than the non-exercise group, but there were no differences in the number of leukocytes, platelets, erythrocytes, sugar levels, cholesterol levels and triglyceride levels. Based on the results of the study it can be concluded that exercise activities are associated with an increase in Hb and hematocrit levels in DM patients at the Jetis Bantul Health Center.