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Phytosome is one of the technologies use to increase bioavailability for Herbal Medicine in developing a new drug delivery system or commonly known as Novel Drug Delivery System (NDDS). a Phytosome is formed by mixing phytokonstituents and phosphatidylcholine in certain molar comparisons. This study aims to develop a phytosome formula of lyophilized powder steeping panda leaves (Pandanus amaryllifolius Roxb.) with a variation of phosphatidylcholine concentration which produces phytosomes with the highest absorption efficiency. Phytosome is formulated by making three variations of catechin comparison: phosphotidylcholine: cholesterol ranging from 1: 1: 0.2 (F1), 1: 2: 0.2 (F2), 1: 3: 0.2 (F3) using the reflux method. Based on the results of the highest percentage percent adsorption efficiency, F2 with the molar ratio of catechins: phosphotidylcholine: 1: 3: 0.2 cholesterol results in 100% adsorption efficiency. So that it is said that phosphatidylcholine has an effect on absorbing catechin compounds in lyophilized powder steeping fragrant panda leaves (Pandanus amaryllifolius Roxb.)