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The kidneys are organs that play an important role in maintaining the balance of body fluid and removing metabolic waste products. The incidence and prevalence of kidneys disease continue to increase throughout the world. Various conditions can cause failure of kidney function. Acute kidney failure (ARF) can increase the risk of chronic kidney failure. The severity of the disease, duration, and frequency of ARF are predictive factors that are important for the patients condition. This study aims to compare the degree of kidney damage based on tubular injury scores in acute and chronic renal failure conditions using an experimental model of ischemic reperfusion injury and renal ablation. Eighteen male Swiss mice will be grouped into 3 treatment groups: the sham operation group (SO, n=6), the ischemic reperfusion injury group (IRI, n=6), and the renal ablation group (RA, n=6). Kidney tissue was stained with hematoxylin-eosin (HE) and tubular injury scores were assessed blindly. This study found that there were significant differences in tubular injury scores between the SO groups (0.43 pm 0.49) and RA (3.6 pm 0.70), but there were no significant differences between the SO groups (0.43 pm 0.49) vs IRI (2.23 pm 0.55) and IRI (2.23 pm 0.55) vs RA (3.6 pm 0.70). Based on the results it can be concluded that there are no differences in tubular injury scores between the ischemic reperfusion injury and renal ablation condition.