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Wireless network technology is currently developing rapidly, especially in the health sector, such as vital sign monitoring. One of the vital sign parameters that are very important to know the condition of the patients circulatory system is blood pressure and body temperature. Examination of blood pressure and body temperature generally uses a sphygmomanometer and thermometer. However, the use of these two tools still has weaknesses in terms of the efficiency of health services because the collection of patient data is still conventional and has not yet developed to the system of sending data wirelessly to the health service unit. This problem becomes to particular concern considering the limited number of medical personnel, the slow pace of health services, especially the results of diagnosing patient diseases, and the administrative costs become to increase. This study aims to assist medical personnel in improving health services, especially in monitoring patients blood pressure and body temperature conditions. The proposed design consists of hardware (MPX5050GP sensor, DS18b20 sensor, LCD, power supply, and laptop) and software (C programming, IDE, MySQL, and Dreamweaver). The results obtained showed that the proposed design worked well with an accuracy level of blood pressure of 97.53% and body temperature of 99.51%.