Diuretic Effect of the Aqueous Extract of Green Tea Leaves Agustina Susilowati
Akademi Farmasi Indonesia Yogyakarta, Indonesia
Abstract
The use of diuretics is needed in situations that require increased water expenditure, one of which is hypertension. Green tea leaves are natural ingredients containing catechin polyphenols (flavonoids). This study aims to determine the diuretic effect of the aqueous extract of green tea leaves (AEGTL). This experimental study using 35 Swiss male mice was divided into 7 groups. Group I was given CMC Na 1%, group II was given dose of furosemide 5.2 mg/KgBB, and group III-VII was given aqueous extract of green tea leaves with doses of 14, 28, 42, 56 and 70 mg/kgBB. Before treatment, all mice were given warm water orally as much as 0.4 ml/20 kgBB. Testing of diuretic effects by measuring urine volume, measurements taken for 6 hours then calculated diuretic activity. From the results of the study obtained the diuretic activity of furosemide is 1.00 and for groups III-VII was given AEGTL respectively 0.53, 0.57, 0.60, 0.71 and 0.91. Green tea causes increase in glomerular filtration rates by increasing blood flow and cardiac output which may contribute to diuretic activity. It can be concluded that AEGTL doses 70mg/kgBB have diuretic activity that is equivalent to furosemide (p <0.05).
Keywords: Diuretic, Aqueous Extract, Green Tea Leaves
Topic: International Symposium of Engineering, Technology, and Health Sciences
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