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Babies with Low Birth Weight (LBW) are a group of babies at high risk. Babies experience various health problems. Problems related to physiological functions and interactions between mother and baby. Therefore, babies with LBW need special care properly and correctly. The kangaroo treatment method provides an opportunity for the baby to be treated together with his mother so that it will increase the bounding attachment between mother and baby. The purpose of this study was to determine the effect of Kangaroo Method Care (KMC) on Changing Interaction between Mother and Baby in perinatology in RSUD Dr. Loeknonohadi Kudus in 2018. This study used a Quasi Experimental design with a design of two groups pretest posttest design, and sampling used a purposive sampling technique with a sample of 28 people. The results of the study found that there were significant differences in mother and child interaction (Bounding Attachment) in the mother group conducted by KMC with a group of mothers who were not performed KMC (p value = 0.002; α: 0.05). It can be concluded that there is an influence of kangaroo method care on mother and baby interaction (Bounding attachment) in the perinatology room of RSUD Dr. Loekmonohadi Hospital in 2018. It is recommended that mothers do routine kangaroo treatment for LBW babies.