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Abstract Sexually-transmitted diseases (STDs) are a group of diseases which are primarily transmitted through sexual contact. STDs become very serious because they may occur with a wide coverage in the world. STDs easily spread from one person to another. The low level of knowledge, attitudes and behavior of the community regarding STDs causes the case to be more of big concern. This study aimed to determine the relationship between knowledge, attitude, and behavior in patient of STDs at Puskesmas Abang I, Karangasem. The study method used was cross-sectional analytic with questionnaires as the instrument. The variables studied were knowledge, attitude, behavior, and occurrence of STDs. The study samples were STDs patients who visited the Puskesmas Abang I, who fulfilled the inclusion and exclusion criteria, numbering 49 people. Sampling was carried out by consecutive sampling method. The collected data were analyzed by using computerized program with Chi-Square test (α = 0,05). The result indicated that there was no relationship between knowledge and attitude (p=1,000), knowledge and behavior (p=0,669) and attitude and behavior (p=0,299). There is a need for counseling to be conducted by Puskesmas Abang I and the need for a program from the Ministry of Health to reduce the occurrence of STDs.