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The research aims to study the relationship between Elaeidobius kamerunicus and oil palm fruit set in the Mambruk Estate oil palm plantation, Papua, Indonesia. The study was conducted from November 2018 to May 2019. The research method used descriptive method by observing Elaeidobius kamerunicus population in 60 male inflorescences and 60 female inflorescences as samples. Data were obtained on the population of Elaeidobius kamerunicus per bunch and per hectare in male and female inflorescence, and the fruit set value of oil palm bunch. Correlation regression test was performed, and an analysis of variance of fruit set values per population grade was continued, followed by DMRT at 5% level. The results showed that in the oil palm plantation in Mambruk estate, Papua, the population of Elaeidobius kamerunicus on male inflorescence had reached the standard, as many as 24,185 individuals per hectare with a fruit set value of 82.18%. There is a positive correlation between Elaeidobius kamerunicus population in female inflorescence and oil palm fruit set. This insect population on female inflorescence influenced by 42.7% on fruit set; There is a positive correlation between Elaeidobius kamerunicus population per male inflorescence and oil palm fruit set. This insect population on male inflorescence influenced by 49.1% on fruit set. The higher population of Elaeidobius kamerunicus, the higher value of oil palm fruit set.