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Stressful is the root from many problems sociological, medical, and economy. Stressful known is factor etiology from any diseases. Prostaglandin and fourth receptor big once the effect to the brain, and even influence behavior so that inactivation cyclooxygenase (COX) which causes decline prostaglandin levels to contribute on the development of stress, so suspected will give away decline effect work anxiolytic from Diazepam. Research when this test influence the administration of selective COX inhibitors and nonselective to effect Anxiolytic diazepam uses method EPM (Elevated Plus Maze) on mice white male. Group of animal Tragakan 2% , Diazepam 0.65 mg / kg BB, Diazepam 0.65 mg / kg BB one hours later Ketoprofen 6.5 mg / kg BB, Diazepam 0.65 mg / kg BW an hour later Selekoksib 6.5 mg / kg BB . Results showing happen decline duration on open arm group has given diazepam combination ketoprofen or celecoxib are different P value <0.05 than diazepam only. Decline duration highest showed by animals given celecoxib so that could be stated gift selective COX-2 inhibitors bring down effect anxiolytic diazepam bigger.