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Background: National Health Insurance has changed the healthcare system in Indonesia and has given impact not only to patients and healthcare facilities but also doctors. Panti Wilasa “Dr. Cipto” Hospital predominantly serve patients with National Health Insurance, so they need to manage doctor-s satisfaction which can affect the quality of service, service effectiveness, patient-s satisfaction and compliance. Clinical autonomy, medical service cost, relationship between nurses and daily practice administration are relevant variables which relate to doctor-s satisfaction at the hospital. Aim: This study aimed to identify doctor specialist-s satisfaction at Outpatient Unit of Panti Wilasa “Dr. Cipto” Hospital in the era of National Health Insurance and its relationship with clinical autonomy, medical service cost, relationship between nurses and daily practice administration. Method: This study was observasional using a cross-sectional design. Data were collected by using questionnaires given to doctors at Outpatient Unit of Panti Wilasa “Dr. Cipto” Hospital. The data were analyzed using Chi square test. Results: The majority of doctors felt unsatisfied (56.6%), and others (43.4%) were satisfied. Daily practice administration (p=0.033) has a significant relationship with doctor-s satisfaction at Outpatient Unit of the hospital. Implication : Identifying doctor-s satisfaction and affecting variables will increase the collaboration between doctors and management, and hopefully medical service will be more effective. Manager-s roles in communicating and doctor-s involvement in formulating hospitals regulation are kind of job enrichment which can develop responsibility, accountability, and belongingness, so doctor-s satisfaction increases.