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Platelet rich plasma (PRP) and platelet rich fibrin (PRF) source from human blood and have play role in bone recovery. Both of them could be incorporated into scaffold. Synthetic coral scaffold is a mimicking from sea coral naturally that designed for bone regeneration. It should have biodegradability and bioabsorbability that influence in new bone formation process. Purpose of this study to investigate the swelling, degradation profile and gel fraction of scaffold that incorporated with PRP or PRF. Synthetic coral scaffold consist of gelatin, calcium carbonate, and sodium nitric as dispersant, divided into 3 group, incorporated PRP, PRF, and No. incorporation. Scaffold was soaked in phosphate buffer saline and incubated in 37 degree C. Scaffold weight was measured in every 30 minutes to observe the profile swelling and gel fraction. Degradation profile was observed after 1, 3, 6, 24, 48, 72, and 96 hours. Acceleration of degradation was measure after soaking with HC1 1N after 1, 3, 6, 24, 48, 72, 96 hours until the scaffold ran out. The result showed significant differences among PRP, PRF, and control group. PRP incorporation have a slow degradation, good swelling and higher gel fraction that presented the strengthen of scaffold structure.